November 26-28, 2009, Henry-Ford Building (FU)
Program of Medical Genome Research

The Program of Medical Genome Research is a large-scale biomedical research program in extension of the National Genome Research Network (NGFN). 156 million Euros have been earmarked for the Program for the years 2008 to 2013 by the German Federal Ministry of Education and Research (BMBF). In the NGFN-Plus sub-program, 26 Integrated Genome Research Networks (IG) focus on the systematic analysis of the molecular basis and on the combating of diseases that are central to health policy. In NGFN-Transfer, eight Innovation Alliances (IA) transfer results from medical genome research into medical and industrial application. The majority of the consortia started their activities in June 2008.
In the program, researchers at more than 60 locations throughout Germany cooperate in the interdisciplinary organized research consortia that connect universities, large research institutes, clinics, and small and medium-sized enterprises. Efficient utilization of research capacities and of the latest technologies on the highest scientific level allows the investigation of the molecular cause of diseases with a high incidence and a particular importance in public health. A central aim is to promote the development of innovative methods for prevention, diagnosis, and therapy of major diseases. The large repertoire of technologies includes functional and structural genomics, proteomics, epigenetics, systems biology, bioinformatics, genetic epidemiology, genotyping, (next-generation) sequencing and proof-of-principle approaches such as animal models.

List of Integrated Genome Research Networks in NGFN-Plus

Integrated Genome
Research Network

Coordination Institution
Brain Tumor Network

Prof. Peter Lichter

DKFZ, Heidelberg

Cellular Systems Genomics in Health and Disease

PD Dr. Stefan Wiemann
DKFZ, Heidelberg
Deciphering Oncogene Dependencies

PD Dr. Roman Thomas

MPI für neurologische Forschung Köln
Epilepsy and Migraine Integrated Network (EMINet)

Prof. Christian Kubisch
Universität Köln

From Disease Genes to Protein Pathways (DiGTOP)

Prof. Wolfgang
Helmholtz Zentrum München
Functional and Translational Genomics of Acute Leukemias

Prof. Christian Hagemeier Charité Berlin
Functional Genomics of Parkinson

Prof. Thomas Gasser Universität Tübingen
Gene Identification and Functional Analyses in Alzheimer´s Disease

PD Dr. Matthias Riemenschneider Universitätsklinikum des Saarlandes, Homburg/Saar
Genetics of Alcohol Addiction

Prof. Rainer

Zentralinstitut für Seelische Erkrankungen

Genetics of Heart Failure

Prof. Hugo Katus Universität Heidelberg
Genome Research Network in Pancreatic Cancer

Prof. Thomas M. Gress Universität Marburg
Genomics of Atherosclerosis Prof. Heribert Schunkert

Universität Lübeck
German Mental Retardation
Network (MRNET)

Prof. André Reis Universität Erlangen
German Mouse Clinic -

Prof. Martin Hrabé
de Angelis

Helmholtz Zentrum München
Integrated Genome Network of Prostate Cancer

PD Dr. Holger Sültmann DKFZ, Heidelberg
Integrated Genomic Investigation
of Colorectal Carcinoma

Prof. Kari Hemminki DKFZ, Heidelberg
MHC Haplotype Sequencing: An Intergrated Approach to Common Disease

Dr. Margret Hoehe MPI für molekulare Genetik Berlin
Modifiers of Intestinal Tumor Formation and Progression

Prof. Bernhard Herrmann MPI für molekulare Genetik Berlin
Molecular Causes of Major Mood Disorders and Schizophrenia (MooDS)

Prof. Markus Nöthen Universität Bonn
Molecular Mechanisms in Obesity Prof. Johannes Hebebrand

Universität Duisburg-Essen
Neuroblastoma Genome
Interaction Network

Prof. Angelika
Universität Duisburg-Essen
Neurodegenerative Diseases Networks (NeuroNet)

Prof. Erich Wanker Max-Delbrück-Zentrum für Molekulare Medizin Berlin
Pathogenic Role of mi-RNA in Herpes-Infections

Prof. Juergen G.
LMU München
RNomics in Infections

Prof. Jürgen Brosius Universität Münster
Systematic Genomics of Chronic Inflammatory Barrier Diseases

Prof. Stefan
Universität Kiel
Systems Biology of Genetic Diseases (Mutanom) Prof. Hans Lehrach MPI für molekulare Genetik Berlin

List of Innovation Alliances in NGFN-Transfer

Integrated Genome
Research Network

Coordination Institution
Anti-malarial Agents Dr. Birte Sönnichsen

Cenix Bioscience Dresden
Breast Cancer Kit

Prof. Jan G. Hengstler Leibniz Institut für Arbeitsphysiologie an der Universität Dortmund

Heart Failure Therapy

Prof. Markus Hecker

Universität Heidelberg
Metabolomic signatures of heart failure

Prof. Hugo Katus Universität Heidelberg
New Tools for the Prevention of Cardiovascular Diseases and Disorders in Chronic Kidney Disease

PD Dr. Joachim Jankowski Charité Berlin
Protein analysis of formalin-fixed tumor (FFPE) samples

PD Dr. Karl-Friedrich Becker

Technische Universität München
Subgenome Fractionation for High Throughput Sequencing

Dr. Bernhard Korn DKFZ, Heidelberg
Whole genome and transcriptome amplification in large biobanks

Prof. H.-Erich Wichmann;
Dr. Christian Korfhage
Helmholtz Zentrum München;
Qiagen GmbH Hilden

The output of the NGFN from 2001 until 2008

includes over 80 patent applications, 2,400 scientific publications, and cooperation in 60 EU projects. The gain in insight into cause and process of disease development through the identification of molecular target structures has lead to a direct transfer of the results into development and optimization of diagnostics and therapeutics. A portfolio of results is ready for in-licensing or collaboration partnerships for further development. The scientists succeeded in discovering genetic variations with implications for Alzheimer's disease, epilepsy, depression, Parkinson’s disease, cancer, susceptibility to allergies, adipositas, coronary heart disease, heart failure and enteritis. They developed DNA chips and identified gene signatures for neuroblastoma, Parkinson's disease, prostate cancer and heart failure that constitute a substantial advance in prognosis and diagnosis. They developed tools against autoimmune diseases, established systematic proof-of-principle approaches such as animal models and cell-based assays, used active semiconductor chips to develop highly complex peptide arrays and optimized micro-endoscopes for brain analysis. In one of the world's largest projects for the analysis of disease-causing genetic variations, the genetic information of up to 25,000 patients and controls is being examined with the help of DNA chips.

Max Planck Institute for Molecular Genetics Freie Universität Berlin Supported Banner Logos