12th – 13th December 2008
Helmholtz Zentrum München / Neuherberg


The Meeting is kindly supported by:







Program

Conference Program Download Flyer Download Abstract Book

Thursday, December 11, 2008
Workshops
1:00 - 4:00 pm Workshop: Next Generation Sequencing
Download Program (PDF)
4:00 - 4:30 pm Coffee Break
4:30 - 8:00 pm Workshop: The NGFN Genome-Wide Association Studies (GWAS) Program for Complex Phenotypes
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8:00 pm Supper
Friday, December 12, 2008
8:30 - 9:00 am Welcome:
Günther Wess, Scientific Director, HMGU
Elmar Nimmesgern, BMBF
Martin Hrabé de Angelis, Speaker Project Committee of NGFN-Plus / NGFN-Transfer in the Program of Medical Genome Research
Symposium I: Genomics of Common Disease
Chairs: Hugo Katus, Stefan Schreiber
9:00 - 9:45 am Keynote: Nilesh Samani, University of Leicester, UK
Genetics of CAD (coronary artery disease): an update
9:45 - 10:00 am Arne Pfeufer, Institute of Human Genetics, Technical University Munich and Helmholtz Zentrum München, Germany
Common variants at ten loci modulate the QT interval duration in individuals of European ancestry: the QTSCD consortium
10:00 - 10:15 am Marcella Rietschel, Central Institute of Mental Health Mannheim, Germany
Genome-wide association study of alcohol dependence
10:15 - 10:30 am Sven Cichon, Life and Brain Center, University of Bonn, Germany
Large recurrent microdeletions associated with schizophrenia
10:30 - 10:45 am Iris Heid, Helmholtz Zentrum München, Germany
Meta-analyses of genome-wide association studies: six new obesity associated loci highlight a neuronal influence on body weight regulation
10:45 - 11:00 am André Franke, Universitätsklinikum Schleswig-Holstein, Kiel, Germany
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kB pathways
11:00 - 11:15 am Thomas Illig, Helmholtz Zentrum München, Germany
Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus
11:15 - 11:45 am Coffee Break
Symposium II: Systems Biology
Chairs: Hans Lehrach, Hans-Werner Mewes
11:45 - 12:15 pm Keynote: Ralf Herwig, Max-Planck-Institute for Molecular Genetics Berlin, Germany
Integration of human molecular interactions
12:15 - 12:30 am Vinayagam Arunachalam, Max Delbrück Center Berlin, Germany
Constructing a causal protein interaction network for activated MAPK signalling
12:30 - 12:45 am Lars Dölken, Max von Pettenkofer-Institute Munich, Germany
High resolution gene expression profiling for simultaneous kinetic parameter analysis of RNA synthesis and decay
12:45 - 1:00 pm Marc Johannes, DKFZ (German Cancer Research Center) Heidelberg, Germany
Predicting pathway membership via domain signatures
1:00 - 3:00 pm Lunch Break and Poster Session I - Posters Symposia I - IV
1:00 - 3:00 pm Company Satellite Lunch Sessions: Download Company Program (PDF)
Roche Diagnostics GmbH - 1) Cell Analyser xCELLigence 2) High Throughput Sequencing with the New Titanium Reagents
Illumina Ltd – Integrative Genetics and Next Generation Sequencing Tools by Illumina
Applied Biosystems GmbH – Ultra High Throughput sequencing analysis of Transcriptome in single cells with SOLiD 3 System
Affymetrix - New Developments for high throughput genotyping and integrated Expression analysis
Symposium III: Genome Regulation
Chairs: Angelika Eggert, Peter Lichter
3:00 - 3:45 pm Keynote: Martin Vingron, Max Planck Institute for Molecular Genetics, Berlin
Computational Regulatory Genomics
3:45 - 4:00 pm Matthias Selbach, Max Delbrück Center Berlin, Germany
Genome-wide identification of microRNA targets by pulsed stable isotope labelling (pSILAC)
4:00 - 4:15 pm Jörg Hoheisel, DKFZ (German Cancer Research Center) Heidelberg, Germany
Looking at microRNA and mRNA profiles and related epigenetic variations in promoter regions of pancreatic cancer samples
4:15 - 4:30 pm Johannes Schulte, Universitätskinderklinik Essen, Germany
Histone demethylase LSD1 is highly expressed in poorly differentiated neuroblastoma and is a novel therapeutic target
4:30 - 4:45 pm Jochen Supper, Center for Bioinformatics Tübingen, Germany
Predicting DNA-binding specificities of transcription factors
4:45 - 5:15 pm Coffee Break
Symposium IV: Animal, Cellular & Tissue Models
Chairs: Stefan Wiemann, Wolfgang Wurst
5:15 - 6:00 pm Keynote: Howard Jacob, Medical College Wisconsin, Milwaukee, USA
The Role of Transgenic Rats in a Genome Wide Association Studies (GWAS) World
6:00 - 6:15 pm Stefan Wiemann, DKFZ (German Cancer Research Center) Heidelberg, Germany
IG-CSG- cellular systems genomics
6:15 - 6:30 pm Jan Rozman, Helmholtz Zentrum München & Technische Universität, Germany
Identification of new targets playing a role in metabolic diseases by systemic analysis in the German Mouse Clinic
6:30 - 6:45 pm Ildikó Rácz, University of Bonn, Germany
Modulation of neuropathic pain by endocannabinoids
6:45 - 7:00 pm Benjamin Meder, University of Heidelberg, Germany
Myosin light chain-1 controls cardiac contractility
Evening Lecture:
7:00 - 8:00 pm Keynote: Matthias Mann, MPI of Biochemistry, Martinsried, Germany
High resolution proteomics in functional genomics
8:00 pm - open end Get-Together, Dinner
Saturday, December 13, 2008
Symposium V: Genomic / Environmental Interaction
Chairs: Markus Nöthen, H.-Erich Wichmann
9:00 - 9:45 am Keynote: Cornelia M. van Duijn, Erasmus University Medical School, Rotterdam, Netherlands
From genome wide association studies to risk prediction: the importance of studies of gene interactions
9:45 - 10:00 am Christian Gieger, Helmholtz Zentrum München, Germany
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
10:00 - 10:15 am Tobias Stoeger, Helmholtz Zentrum München, Germany
Response to ultrafine particle instillation in two mouse strains with extremely divergent lung function
10:15 - 10:30 am Rainer Spanagel, Central Institute of Mental Health Mannheim, Germany
Alcoholism – A Systems approach from molecular physiology to addictive behaviour
10:30 - 10:45 am Hadi Al-Hasani, German Institute for Human Nutrition Nuthetal
Tbc1d1 mutation confers leanness and protects from diet-induced obesity and diabetes
10:45 - 12:45 pm Lunch Break and Poster Session II - Posters Symposia V-VI
10:45 - 12:45 pm Company Satellite Lunch Sessions: Download Company Program (PDF)
Roche Diagnostics GmbH – LightCycler 480 System (Real-Time PCR)
Illumina Ltd - Genotyping and Gene-expression updates from Illumina
TMF e.V. - Contact partner and common platform for networked medical research
Symposium VI: Transfer from Genomics to Application
Chairs: Markus Hecker, Birte Sönnichsen
12:45 - 1:30 pm Keynote: Bert Klebl, Lead Discovery Center GmbH, Dortmund, Germany
From Genomes to Drugs
1:30 - 1:45 pm Martin Sos, Max Planck Institute for Neurological Research Cologne, Germany
Defining PI3-Kinase dependency in non-small cell lung cancer
1:45 - 2:00 pm Eva Lattka, Helmholtz Zentrum München, Germany
Functional impact of polymorphisms on the human delta-6 desaturase gene promoter
2:00 - 2:15 pm Nicole Huebener, Charité – University Medicine Berlin, Germany
Xenogeneic immunization with human tyrosine hydroxylase DNA vaccines effectively eradicates established neuroblastoma and induces long lasting protective immunity
2:15 - 2:30 pm Michal-Ruth Schweiger, Max Planck Institute for Molecular Genetics, Berlin, Germany
High-throughput sequencing of snap frozen and paraffin embedded cancer and normal tissues
2:30 - 2:45 pm Isabel von Korff, Competence Center Technology Transfer (KTT)
Technology transfer in the program for medical genome research

2:45 - 3:00 pm Ceremony: , “Annemarie Poustka Poster Award of Medical Genome Research” sponsored by Roche Diagnostics GmbH
Posteraward
2:45 - 3:00 pm Concluding Remarks: Hugo Katus, Speaker Project Committee of NGFN-Plus / NGFN-Transfer in the Program of Medical Genome Research